QFT Gold Testing Process

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Team ID: 
1064
College / Administrative Unit: 
Student Affairs
Date Started: 
May 2012
Objective: 

The purpose of this study is to monitor the results of Quantiferon testing for TB. This test is utilized during international screening and is important for the detection of active/latent TB. False positive results can be an issue and the rate of positivity will be monitored.

Results: 

Expected Results: 5-14-13

  • Reviewed sample collection technique with all laboratory staff. Samples must be shaken immediately after collection and should be drawn gray, red, purple in order.
  • Tubes are now incubated in 37 degree incubator.
  • The incubation time was reviewed and found to be acceptable. (16 -24 hours)
  • Sent staff member to ASCLS spring meeting for QFT presentation by Dr. Richard Clark.
  • Laboratory manager met with Qiagen Cellestis representative (company that makes QFT assay) to discuss concerns. It was discovered that 2 lot numbers of tubes were reported by outside labs to show increase in positive rates; however, studies by the R&D team were unable to recreate the issue. UHS lab began tracking lot numbers in LIS inventory.
  • Benchmarking was conducted with other universities.
  • In July 2012, an internal comparison study was conducted against T-spot, another interferon assay for TB. 100% agreement was found.
  • September 2012, Based upon the LIS tracking system, it was determined that these lot numbers were not in lab inventory.
Contact Person: 
Nancy Lambert
Members:
  • Vicki Dugan, Leader
  • Sharon Fong, Member
  • Janet Nelson, Member
  • Judith Novack, Member